Research · Publications · Partnerships

The Science of the
Entrepreneurial Mind

Peer-reviewed research at the intersection of entrepreneurship, neuroscience, and mental wellness.

Landmark Research · 2015 & 2019

"Are Entrepreneurs Touched with Fire?"

The original paper · 2015 · unpublished. "Are Entrepreneurs Touched with Fire?" was never published in a peer-reviewed journal. Written in 2015, it went viral immediately, reaching over 100,000 readers around the world — the paper that ignited the movement.
Authors: Freeman, Johnson, Staudenmaier & Zisser

Read the Original Paper →
The peer-reviewed version · 2019. Freeman, M.A., Staudenmaier, P. J., Zisser, M. R., & Andresen, L. A. (2019). The prevalence and co-occurrence of psychiatric conditions among entrepreneurs and their families. Small Business Economics, 53(2), 323–342. Accessed over 123,000 times.
Authors: Freeman, Staudenmaier, Zisser & Andresen

Read the Peer-Reviewed Version →
Key Finding
"Entrepreneurs have disproportionately high rates of mental health differences — and these same traits drive exceptional performance."
100K+
Readers worldwide of the
original 2015 paper
123K+
Accesses of the
peer-reviewed version
2019
Published in peer-reviewed
Small Business Economics, 53(2)
The Science Behind FounderScreen

Meet the science behind FounderScreen

FounderScreen is an evidence-based program designed to build resilience, wellbeing, performance optimization and mental health among entrepreneurs.

If you would like to learn more about the science behind FounderScreen, we’d love to share the underlying research with you. Here you will find some of the most important studies in the FounderScreen evidence base. Access to additional research is available within FounderScreen itself, linked to each of the strength-building learning labs.

These studies may be of interest to executive coaches and mental health clinicians who work with entrepreneurs. If you are working with a coach or clinician, feel free to refer them to this bibliography. And if you are a business builder who would like to learn, this is a great place to read the original technical reports. If reading scientific literature is not for you, just work your way through the FounderScreen journey and focus on being your best self as an entrepreneur. And the podcasts, webcasts, and “recommended reading” books you will find elsewhere on this site were created with you in mind, so check out any that may be of interest.

Econa-authored research — Dr. Freeman is a primary author or co-author
Neurodiversity and Neuroscience

Freeman, M.A., Johnson, S.L., Staudenmaier, P.J., & Zisser, M.R.; Are entrepreneurs touched with fire? (2015). Never published in a peer-reviewed journal, and the paper Dr. Freeman credits with igniting the movement — it went viral immediately, reaching over 100,000 readers worldwide. Its peer-reviewed successor is the 2019 paper listed here, which carries a different title and a different author list. → Read

Freeman, M.A., Lerner, D., & Rauch, A. (2024). Dopamine and entrepreneurship: Unifying entrepreneur personality traits, psychiatric symptoms, entrepreneurial action and outcomes. Journal of Business Venturing Insights, 21, e00461. → Read

Alexander-Passe, N. (2025). Neurodiversity entrepreneurship: When enough is never enough. Asia Pacific Journal of Developmental Differences, 12(2). → Read

DeYoung, C. G. (2013). The neuromodulator of exploration: A unifying theory of the role of dopamine in personality. Frontiers in Human Neuroscience, 7, 63203. → Read

Sharma, G. D., Paul, J., Srivastava, M., Yadav, A., Mendy, J., Sarker, T., & Bansal, S. (2021). Neuroentrepreneurship: An integrative review and research agenda. Entrepreneurship & Regional Development, 33(9–10), 863–893. → Read

Wiklund, J., Hatak, I., Patzelt, H., & Shepherd, D. A. (2018). Mental disorders in the entrepreneurship context: When being different can be an advantage. Academy of Management Perspectives, 32(2), 182–206. → Read

Wiklund, J., Tran, M. H., & Rahm, R. (2024). Neurodiversity and entrepreneurship. In Neurodiversity and Work: Employment, Identity, and Support Networks for Neurominorities (pp. 283–309). Cham: Springer Nature Switzerland. → Read

Entrepreneur Wellbeing Enhances Emotional Stability and Success

Bouaddi, M., & Chraibi, S. (2026). Psychological well-being and innovative work behaviour among entrepreneurs: A systematic review and integrative theoretical framework. A Journal of Entrepreneurship and Business Strategies, 2(2), 10–20. → Read

Dijkhuizen, J., Gorgievski, M., van Veldhoven, M., & Schalk, R. (2018). Well-being, personal success and business performance among entrepreneurs: A two-wave study. Journal of Happiness Studies, 19(8), 2187–2204. → Read

Stephan, U. (2018). Entrepreneurs' mental health and well-being: A review and research agenda. Academy of Management Perspectives, 32(3), 290–322. → Read

Tisu, L., Vîrgă, D., & Taris, T. (2023). Entrepreneurial well-being and performance: Antecedents and mediators. Frontiers in Psychology, 14, 1112397. → Read

Wiklund, J., Nikolaev, B., Shir, N., Foo, M. D., & Bradley, S. (2019). Entrepreneurship and well-being: Past, present, and future. Journal of Business Venturing, 34(4), 579–588. → Read

Happy Entrepreneurs are Emotionally Stable and Productive

Baron, R. A., & Tang, J. (2011). The role of entrepreneurs in firm-level innovation: Joint effects of positive affect, creativity, and environmental dynamism. Journal of Business Venturing, 26(1), 49–60. → Read

Baluku, M. M., Kikooma, J. F., & Otto, K. (2018). Positive mindset and entrepreneurial outcomes: The magical contributions of psychological resources and autonomy. Journal of Small Business & Entrepreneurship, 30(6), 473–498. → Read

Díaz-Pincheira, F., Acosta-Antognoni, H., & Salanova, M. (2025). Effects of positive psychological capital on entrepreneurial success: A systematic review. Intangible Capital, 21(2), 290–310. → Read

Fodor, O. C., & Pintea, S. (2017). The "emotional side" of entrepreneurship: A meta-analysis of the relation between positive and negative affect and entrepreneurial performance. Frontiers in Psychology, 8, 310. → Read

Portocarrero, F. F., Newbert, S. L., Young, M. J., & Zhu, L. Y. (2025). The affective revolution in entrepreneurship: An integrative conceptual review and guidelines for future investigation. Journal of Management, 51(6), 2419–2459. → Read

Resilient Entrepreneurs are Emotionally Stable and Productive

Ayala, J. C., & Manzano, G. (2014). The resilience of the entrepreneur. Influence on the success of the business. A longitudinal analysis. Journal of Economic Psychology, 42, 126–135. → Read

Corner, P. D., Singh, S., & Pavlovich, K. (2017). Entrepreneurial resilience and venture failure. International Small Business Journal, 35(6), 687–708. → Read

Fatoki, O. (2018). The impact of entrepreneurial resilience on the success of small and medium enterprises in South Africa. Sustainability, 10(7), 2527. → Read

Fisher, R., Maritz, A., & Lobo, A. (2016). Does individual resilience influence entrepreneurial success? Academy of Entrepreneurship Journal, 22(2), 39–53. → Read

Socially embedded entrepreneurs are emotionally stable and productive

Baron, R. A., & Tang, J. (2009). Entrepreneurs' social skills and new venture performance: Mediating mechanisms and cultural generality. Journal of Management, 35(2), 282–306. → Read

Baron, R. A., & Markman, G. D. (2000). Beyond social capital: How social skills can enhance entrepreneurs' success. Academy of Management Perspectives, 14(1), 106–116. → Read

McKeever, E., Anderson, A., & Jack, S. (2014). Social embeddedness in entrepreneurship research: The importance of context and community. In Handbook of Research on Small Business and Entrepreneurship (pp. 222–236). Edward Elgar Publishing. → Read

Mittal, S., Dhand, S., & Nghiem, X. H. N. (2025). Social support networks and their role in entrepreneurial well-being. In Supporting Psychological and Emotional Wellbeing Among Entrepreneurs (pp. 319–344). IGI Global Scientific Publishing. → Read

Newman, A., Mole, K. F., Ucbasaran, D., Subramanian, N., & Lockett, A. (2018). Can your network make you happy? Entrepreneurs' business network utilization and subjective well-being. British Journal of Management, 29(4), 613–633. → Read

Effective entrepreneurs are emotionally stable and productive

Ahlin, B., Drnovšek, M., & Hisrich, R. D. (2014). Entrepreneurs' creativity and firm innovation: The moderating role of entrepreneurial self-efficacy. Small Business Economics, 43(1), 101–117. → Read

Baum, J. R., & Locke, E. A. (2004). The relationship of entrepreneurial traits, skill, and motivation to subsequent venture growth. Journal of Applied Psychology, 89(4), 587–598. → Read

Caliendo, M., Kritikos, A. S., Rodriguez, D., & Stier, C. (2023). Self-efficacy and entrepreneurial performance of start-ups. Small Business Economics, 61(3), 1027–1051. → Read

Glosenberg, A., Phillips, D., Schaefer, J., Pollack, J. M., Kirkman, B. L., McChesney, J., … & Foster, L. L. (2022). The relationship of self-efficacy with entrepreneurial success: A meta-analytic replication and extension. Journal of Business Venturing Insights, 18, e00342. → Read

Miao, C., Qian, S., & Ma, D. (2017). The relationship between entrepreneurial self-efficacy and firm performance: A meta-analysis of main and moderator effects. Journal of Small Business Management, 55(1), 87–107. → Read

Emotion regulation makes entrepreneurs emotionally stable and productive

Schmodde, L., & Wehner, M. C. (2024). Integrating emotion regulation, emotional intelligence, and emotion-focused coping in the entrepreneurial context: A review and research agenda. International Small Business Journal, 42(8), 984–1015. → Read

Banerjee, P., & Pathak, R. (2026). Entrepreneurial emotional regulation and its role in founder resilience and sustained business success in India. International Journal of Innovative Science and Research Technology (IJISRT), IJISRT26JUN404, 51–56. DOI: 10.38124/ijisrt/26Jun404. → Read

Well-rested entrepreneurs are emotionally stable and productive

Williamson, A. J., Battisti, M., Leatherbee, M., & Gish, J. J. (2019). Rest, zest, and my innovative best: Sleep and mood as drivers of entrepreneurs' innovative behavior. Entrepreneurship Theory and Practice, 43(3), 582–610. → Read

Michaud, X., Guiliani, F., Ballesteros Leiva, F., & Simonelli, G. (2026). Entrepreneurs and sleep: A scoping review of barriers, recovery strategies, and effects on performance. Small Business Economics, 1–27. → Read

Brain Economy

Eyre, H. A., Freeman, M.A., Ayadi, R., Ellsworth, W., Aragam, G., Smith, E., Dawson, W. D., … & Hynes, W. (2021). Building brain capital. Neuron, 109(9), 1430–1432. → Read

Abbott, R. et al. (2022). Brain health-directed policymaking; a new concept to strengthen democracy. Brookings Global Economy and Development Program, working paper #178, October 2022. → Read  → Mirror copy

Iddouch, K. (2026). Brain capital at the frontier of knowledge, a systematic literature review and bibliometric analysis of an emerging transdisciplinary fields. → Read

Screening and Detection

Freeman, M.A., Mazza, A., Johnson, S. L., & Heinz, A. J. (2026). The entrepreneur well-being check: A screener for entrepreneur mental health and well-being. International Journal of Entrepreneurial Behavior & Research, 32(5), 1333–1354. → Read

Entrepreneur Psychology and Mental Health
Overview

Freeman, M.A., Staudenmaier, P. J., Zisser, M. R., & Andresen, L. A. (2019). The prevalence and co-occurrence of psychiatric conditions among entrepreneurs and their families. Small Business Economics, 53(2), 323–342. → Read

Hunt, R. A., Lerner, D. A., Johnson, S. L., Badal, S., & Freeman, M.A. (2022). Cracks in the wall: Entrepreneurial action theory and the weakening presumption of intended rationality. Journal of Business Venturing, 37(3), 106190. → Read

Frese, M., & Gielnik, M. M. (2014). The psychology of entrepreneurship. Annual Review of Organizational Psychology and Organizational Behavior, 1(1), 413–438. → Read

Frese, M., & Gielnik, M. M. (2023). The psychology of entrepreneurship: Action and process. Annual Review of Organizational Psychology and Organizational Behavior, 10(1), 137–164. → Read

Attention Deficit Hyperactivity Disorder (ADHD)

Yu, W., Wiklund, J., & Pérez-Luño, A. (2021). ADHD symptoms, entrepreneurial orientation (EO), and firm performance. Entrepreneurship Theory and Practice, 45(1), 92–117. → Read

Autism Spectrum Disorder (ASD)

Patton, E. (2022). The push and pull of entrepreneurship for individuals with autism spectrum disorder. In Research Handbook on Disability and Entrepreneurship (pp. 59–76). Edward Elgar Publishing. → Read

Behavioral Addictions

Spivack, A. J., & McKelvie, A. (2021). Measuring addiction to entrepreneurship. Journal of Business Venturing Insights, 15, e00212. → Read

Bipolar Spectrum

Johnson, S. L., Madole, J. W., & Freeman, M.A. (2018). Mania risk and entrepreneurship: Overlapping personality traits. Academy of Management Perspectives, 32(2), 207–227. → Read

Johnson, S. L., Murray, G., Hou, S., Staudenmaier, P. J., Freeman, M.A., Michalak, E. E., & CREST.BD. (2015). Creativity is linked to ambition across the bipolar spectrum. Journal of Affective Disorders, 178, 160–164. → Read

Johnson, S. L., Freeman, M.A., & Staudenmaier, P. J. (2015). Mania risk, overconfidence, and ambition. Journal of Social and Clinical Psychology, 34(7), 611–621. → Read

Burnout

Lechat, T., & Torrès, O. (2017). Stressors and satisfactors in entrepreneurial activity: An event-based, mixed methods study predicting small business owners' health. International Journal of Entrepreneurship and Small Business, 32(4), 537–569. → Read

Omrane, A., Kammoun, A., & Seaman, C. (2018). Entrepreneurial burnout: Causes, consequences and way out. FIIB Business Review, 7(1), 28–42. → Read

Depression

Cubbon, L., Darga, K., Wisnesky, U. D., Dennett, L., & Guptill, C. (2021). Depression among entrepreneurs. Small Business Economics, 57(2), 781–805. → Read

Hessels, J., Rietveld, C. A., Thurik, A. R., & Van der Zwan, P. (2018). Depression and entrepreneurial exit. Academy of Management Perspectives, 32(3), 323–339. → Read

Van Doren, N., Tharp, J. A., Johnson, S. L., Staudenmaier, P. J., Anderson, C., & Freeman, M.A. (2019). Perseverance of effort is related to lower depressive symptoms via authentic pride and perceived power. Personality and Individual Differences, 137, 45–49. → Read

Dyslexia

Halfpenny, J., & Halfpenny, C. (2012). In their element: The case for investing in dyslexic entrepreneurs. A report published by Halfpenny Development Ltd. → Read

Kruse, E. (2025). Dyslexia and entrepreneurship: Exploring how early adversity, coping strategies, and self-efficacy shape the entrepreneurial journeys of individuals with dyslexia (Doctoral dissertation, Durham University). → Read

Negative Emotionality

Williamson, A. J., Drencheva, A., & Wolfe, M. T. (2024). When do negative emotions arise in entrepreneurship? A contextualized review of negative affective antecedents. Journal of Small Business Management, 62(1), 209–253. → Read

Obsessive Compulsive Personality Disorder (OCPD)

Wolfe, M. T., & Patel, P. C. (2017). Persistent and repetitive: Obsessive-compulsive personality disorder and self-employment. Journal of Business Venturing Insights, 8, 125–137. → Read

Personality

Entrepreneurs with a specific personality profile are more successful. Abbreviated as E++ C+- O++ N-- A na, (not applicable), you can learn more about this here.

Brandstätter, H. (2011). Personality aspects of entrepreneurship: A look at five meta-analyses. Personality and Individual Differences, 51(3), 222–230. → Read

Zhao, H., & Seibert, S. E. (2006). The big five personality dimensions and entrepreneurial status: A meta-analytical review. Journal of Applied Psychology, 91(2), 259–271. → Read

PTSD

Jones Christensen, L., & Embry, E. (2026). Now you see it: Using a trauma-informed lens to redirect conversations on health, human capital and entrepreneurship. International Journal of Entrepreneurial Behavior & Research, 32(5), 1156–1178. → Read

Halko, M. L., Lahti, T., Hytönen, K., & Jääskeläinen, I. P. (2017). Entrepreneurial and parental love—are they the same? Human Brain Mapping, 38(6), 2923–2938. → Read

Resilience

Hartmann, S., Backmann, J., Newman, A., Brykman, K. M., & Pidduck, R. J. (2022). Psychological resilience of entrepreneurs: A review and agenda for future research. Journal of Small Business Management, 60(5), 1041–1079. → Read

Santoro, G., Messeni-Petruzzelli, A., & Del Giudice, M. (2021). Searching for resilience: The impact of employee-level and entrepreneur-level resilience on firm performance in small family firms. Small Business Economics, 57(1), 455–471. → Read

Sleep

Michaud, X., Guiliani, F., Ballesteros Leiva, F., & Simonelli, G. (2026). Entrepreneurs and sleep: A scoping review of barriers, recovery strategies, and effects on performance. Small Business Economics, 1–27. → Read

Populations and Sub-populations

Africa: Flourish Ventures Endeavor Launch Africa Econa Startup Snapshot (2023). African founders’ wellbeing report. → Read

Brazil: Endeavor (2023). Health and performance of high-impact entrepreneurs. → Read

Canada: Business Development Bank of Canada (2025). 7th annual report of the mental health of Canadian entrepreneurs. → Read

Canada: Canadian Mental Health Association (2019). Going it alone: The mental health and well-being of Canada's entrepreneurs. → Read

India: Jagah (2024). Founders' wellbeing: The emotional journey of Indian entrepreneurs. → Read

International: Startup Snapshot (2023). The untold toll: The impact of stress on the well-being of startup founders and CEOs. → Read

Latin America and the Caribbean: Pan American Development Bank (2023). The invisible factor: How well-being and mental health can improve the high-impact entrepreneurship ecosystem in Latin America and the Caribbean. → Read

New Zealand: Callaghan Innovation (2023). Kiwi founders' wellbeing: Experiences and needs. → Read

Women: Zisser, M. R., Johnson, S. L., Freeman, M.A., & Staudenmaier, P. J. (2019). The relationship between entrepreneurial intent, gender and personality. Gender in Management: An International Journal, 34(8), 665–684. → Read

Military Veterans: Heinz, A. J., Freeman, M.A., Harpaz-Rotem, I., & Pietrzak, R. H. (2017). American military veteran entrepreneurs: A comprehensive profile of demographic, service history, and psychosocial characteristics. Military Psychology, 29(6), 513–523. → Read

Open Science

The Entrepreneur Wellbeing Check is in the public domain and free to use.

The EWC is a validated, peer-reviewed instrument built specifically for entrepreneurs — not adapted from general-population tools. Published 2026. Validated with 314 entrepreneurs across the US, Canada, the EU, the UK, and Israel.

Peer-Reviewed Published 2026 314 Validated Public Domain
Take the Free EWC →
A Global Research Community

Institutional Collaborators

Econa collaborates with university-based entrepreneurship departments and leading entrepreneurship researchers around the world. Together we build the scientific foundation to improve entrepreneur resilience, wellbeing, mental health and performance at scale.

UC Berkeley
Co-investigator: Prof. Sheri L. Johnson, Distinguished Professor of Psychology.

Lead academic partner on the Entrepreneur Wellbeing Check study and the FounderScreen Initiative.
Wharton Neuroscience Initiative
Active collaboration on entrepreneur brain capital. Featured in Wharton Magazine: "Investing in the Founder's Brain." A platform for translating neuroscience research into practical frameworks for entrepreneurship ecosystems.
Frequently Asked Questions

The research, answered

What scientific research supports the Entrepreneur Wellbeing Check?

The EWC was developed and validated with 314 entrepreneurs across the US, Canada, EU, UK and Israel, and published as a peer-reviewed validation study in the International Journal of Entrepreneurial Behavior & Research (2026).

What did Dr. Freeman's founding research show?

His landmark studies — including the 2019 peer-reviewed study in Small Business Economics with over 123,000 accesses — found that entrepreneurs experience significantly higher rates of mental health differences, and that these traits correlate with entrepreneurial performance.

Can other researchers use the EWC?

Yes. The Entrepreneur Wellbeing Check is in the public domain and free to use — placed there deliberately so it can be used by anyone, in order to maximize its impact.